Novel bile salt analogs reduce lipid accumulation in liver cells with potential to treat both metabolic dysfunction-associated steatotic liver disease and Clostridioides difficile infection
Defeng Cai, Huy Nguyen, Yang Zhang, S T Bahade A S Lanje and S J Sharma S T Bahade A S Lanje and S J Sharma, Angel Schilke, Rola Raychouni, Efren Heredia, Ernesto Abel‐Santos, Steven M. Firestine, W.T. Liu
The paper screens bile salt analogs to identify compounds that reduce lipid accumulation in liver cells and inhibit C. difficile spore germination, offering potential dual therapy for MASLD and CDI.
bioRxiv · Jun 16, 2026 · PreprintPharmacology & Toxicology