Author

Andrew M. Fribley

Wayne State UniversityORCID 0000-0002-2046-1600Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lawrence I. GrossmaniD· 3 shared Neeraja PurandareiD· 3 shared Siddhesh ArasiD· 3 shared Yue XiiD· 3 shared Caleb VeghiD· 2 shared Vignesh PasupathiiD· 2 shared Adi Laurentiu TarcaiD· 1 shared Gaurav BhattiiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Lawrence I. GrossmanORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 3, 2026

MNRR1 is required for Triple Negative Breast Cancer growth and metastasis and can be targeted by repurposed drugs.

Mrunal Sathe, Paige M. Minchella, Caleb Vegh…·Siddhesh Aras

This study identifies MNRR1 as a critical driver of TNBC growth and metastasis, showing it can be targeted by existing drugs.

DOI 10.64898/2026.01.31.703055

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintOct 7, 2024

Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS

Neeraja Purandare, Vignesh Pasupathi, Yue Xi…·Siddhesh Aras

The paper identifies nitazoxanide and tizoxanide as compounds that increase MNRR1 levels, improving mitochondrial function in MELAS by inhibiting HIF2α-mediated transcriptional suppression.

DOI 10.1101/2024.10.07.617011

humanexperimental assay

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Molecular BiologybioRxivPreprintNov 6, 2021

Lipopolysaccharide induces placental mitochondrial dysfunction by reducing MNRR1 levels via a TLR4-independent pathway

Neeraja Purandare, Yusef Kunji, Yue Xi…·Siddhesh Aras

This study shows that lipopolysaccharide reduces MNRR1 levels in placental tissues, leading to mitochondrial dysfunction and inflammation via a TLR4-independent pathway.

DOI 10.1101/2021.11.06.467519

mousebulk RNA-seq

𝕏 PostBluesky