BiochemistrybioRxivPreprint
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MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity
T. Hsu, Xi Wang, Jiayan Zhang…·Sun Hur
Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.
DOI 10.64898/2026.01.27.702129