The paper identifies distinct B-cell differentiation and activation profiles in RA synovial fluid, highlighting increased extrafollicular plasmablast differentiation in ACPA-positive RA.

bioRxiv · Sep 29, 2026 · PreprintImmunology

MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity

T. Hsu, Xi Wang, Jiayan Zhang, Yukari Isayama, Viktoria E. M. Schindler, Eveline Van Gompel, Hadil Maadadi, Celia Torres-Arancivia, Akiko Shimazaki-Takahashi, Nina Kurihara, Mariko Kondo, Marina Galesic, Antonella Notarnicola, Sharmin Sultana, A. Maeda, , Sun Hur

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

bioRxiv · Jul 31, 2026 · PreprintBiochemistry✦ In-depth digest

Anti-MDA5 monoclonal antibodies from patients with dermatomyositis - B cell characteristics and differential targeting of the helicase domains

Eveline Van Gompel, Marina Galesic, Nicolas Delaroque, Karolin Kern, Ragnhild Stålesen, Antonella Notarnicola, Deniz Demirdal, Monika Hansson, Annika van Vollenhoven, Edvard Wigren, S. Gräslund, Michael Szardenings, Vivianne Malmström, Ingrid E. Lundberg, Begum Horuluoglu, , Vijay Joshua

The paper identifies anti-MDA5 monoclonal antibodies from DM patients, showing they target distinct epitopes within the helicase domains of MDA5.

Journal of Autoimmunity · Feb 19, 2026Peer-reviewedImmunology