A dynamic molecular glue targets a plastic MDA5 filament interface to stimulate innate immunity
This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.
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Brigham and Women's HospitalORCID 0000-0003-1041-8040Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.
T. Hsu, Xi Wang, Jiayan Zhang…·Sun Hur
Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.
Jie Chen, Zongchao Mo, Sixing Chen…·Roger A. Greenberg
The paper identifies immunogenic endogenous dsRNAs by isolating MDA5 filaments and shows their suppression by ADAR1 and DDX3X.