Eveline Van Gompel

MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

Anti-MDA5 monoclonal antibodies from patients with dermatomyositis - B cell characteristics and differential targeting of the helicase domains

The paper identifies anti-MDA5 monoclonal antibodies from DM patients, showing they target distinct epitopes within the helicase domains of MDA5.

Serum from patients with Idiopathic inflammatory myopathy induces skeletal muscle weakness

This study shows that serum from IIM patients reduces skeletal muscle force, but isolated IgG does not, suggesting humoral factors directly cause muscle weakness.