PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance
Pragya Parashara, Bethan Medina‐Pritchard, Maria Alba Abad, Paula Sotelo‐Parrilla, Reshma Thamkachy, David Grundei, Juan Zou, Christos Spanos, Chandni Natalia Kumar, Claire Minard‐Basquin, Vimal Das, Zhaoyue Yan, Asma Abdullah Abdulwahab Al-Murtadha, David A. Kelly, Toni McHugh, , A. Arockia Jeyaprakash
The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.
Science · Sep 5, 2024Peer-reviewedCell Biology