Chromatin adaptors and TOPBP1 condensates cooperate to organize ATM signaling
Clémence Mooser, Jihane Basbous, Nathalie Varisco, Tom Egger, Mònica Torres Esteban, Johannes Leyrer, Andrea Hänel, Vira Chea, Alain Jeanrenaud, Angelos Constantinou, Manuel Stucki
This study identifies Treacle and NBS1 as components of TOPBP1 condensates that activate ATM signaling and show their cooperative role in organizing DNA damage responses.
bioRxiv · Aug 21, 2026 · PreprintCell Biology