Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS
Elsa Zacco, Martina Gilodi, Abigail Dos Santos, Alexandros Armaos, Rachel James, Francesco Di Palma, Fergal M. Waldron, Marco Scotto, Jakob Rupert, Vlad Korobeynikov, Neil A. Shneider, Mathew H. Horrocks, Jenna M. Gregory, Gian Gaetano Tartaglia
This study uses RNA aptamers to detect pathological FUS in ALS, showing improved specificity and sensitivity compared to antibodies.
bioRxiv · Apr 30, 2025 · PreprintBiochemistry