Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity
C. J. Fritschi, S. Anang, Z. Gong, M. Mohammadi, J. Richard, C. Bourassa, K. T. Severino, H. Richter, D. Yang, H.-C. Chen, T.-J. Chiu, M. Seaman, N. Madani, C. Abrams, A. Finzi, , A. B. Smith
This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.
bioRxiv · Jan 2, 2023 · PreprintMicrobiology