Author

M. Seaman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:rat· 1 Organism:virus· 1

Frequent Co-Authors

C. Lavine· 2 shared A. B. Smith· 1 shared A. Bartesaghi· 1 shared A. Finzi· 1 shared A. Foulger· 1 shared A. Gautam· 1 shared A. L. Hsu· 1 shared A. Moody· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. Lavine

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

C. J. Fritschi, S. Anang, Z. Gong, M. Mohammadi, J. Richard, C. Bourassa, K. T. Severino, H. Richter, D. Yang, H.-C. Chen, T.-J. Chiu, M. Seaman, N. Madani, C. Abrams, A. Finzi, , A. B. Smith

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

bioRxiv · Jan 2, 2023 · PreprintMicrobiology

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

J. Zhang, Y. Cai, C. Lavine, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, M. Mayer, S. Rits-Volloch, S. Wang, P. Sliz, D. Wesemann, W. Yang, M. Seaman, , B. Chen

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

bioRxiv · Jan 11, 2022Biochemistry

Neutralizing activity of broadly neutralizing anti-HIV-1 antibodies against primary African isolates

J. C. C. Lorenzi, P. Mendoza, Y. Z. Cohen, L. Nogueira, C. Lavine, J. Sapiente, M. Seaman, M. Wiatr, N. R. Mugo, A. Mujugira, S. Delany, J. R. Lingappa, C. Celum, M. Caskey, M. C. Nussenzweig

This study evaluates the neutralizing activity of 9 anti-HIV-1 bNAbs against primary African isolates, finding reduced potency and breadth compared to pseudotyped viruses.

bioRxiv · Sep 24, 2020Immunology

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

W. B. Williams, R. Meyerhoff, R. J. Edwards, H. Li, N. Nicely, R. Henderson, Y. Zhou, K. Janowska, K. Mansouri, K. Manne, V. Stalls, A. L. Hsu, M. J. Borgnia, G. Stewart-Jones, M. S. Lee, , B. F. Haynes

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

bioRxiv · Jun 30, 2020 · PreprintImmunology