Author

W. A. McEwan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. J. Tuck· 2 shared L. C. James· 2 shared T. Katsinelos· 2 shared A. J. Fletcher· 1 shared A. K. Davies· 1 shared C. Knox· 1 shared C. S. Green· 1 shared D. Boken· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

B. J. Tuck

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains

C. S. Green, K. F. Winklhofer, A. J. Fletcher, L. C. James, J. Skidmore, J. Duce, W. A. McEwan

This study identifies HOIP and linear ubiquitin chains as critical for TRIM21-mediated ADIN by recruiting VCP, enhancing virus neutralization.

bioRxiv · Apr 2, 2024 · PreprintImmunology

Characterization and super-resolution imaging of small tau aggregates in human samples.

D. Boken, D. Cox, M. Burke, J. Y. L. Lam, T. Katsinelos, J. S. H. Danial, W. A. McEwan, J. Rowe, D. Klenerman

The paper develops a method to detect and characterize small tau aggregates in human samples, revealing disease-specific morphological and compositional differences.

bioRxiv · Jun 12, 2023Biochemistry

Perforin-2 is a pore-forming effector of endocytic escape in cross- presenting dendritic cells

P. Rodriguez-Silvestre, M. Laub, A. K. Davies, J. P. Schessner, P. A. Krawczyk, B. J. Tuck, W. A. McEwan, G. H. H. Borner, P. Kozik

The paper identifies perforin-2 as a pore-forming protein essential for endocytic escape in cross-presenting dendritic cells, enabling antigen processing for MHC class I presentation.

bioRxiv · Jan 31, 2023Cell Biology

Tau assemblies enter the cytosol in a cholesterol sensitive process essential to seeded aggregation

B. J. Tuck, L. V. C. Miller, E. L. Wilson, T. Katsinelos, S. Cheng, M. J. Vaysburd, C. Knox, L. Tredgett, E. Metzakopian, L. C. James, W. A. McEwan

The paper investigates how tau assemblies enter the cytosol, finding that cholesterol levels and specific cellular machinery are critical for this process, which is essential for seeded aggregation.

bioRxiv · Jun 21, 2021Cell Biology