K. F. Winklhofer

Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains

This study identifies HOIP and linear ubiquitin chains as critical for TRIM21-mediated ADIN by recruiting VCP, enhancing virus neutralization.

Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival

This study shows that linear ubiquitination at damaged lysosomes activates NF-κB and promotes cell survival through lysophagy.

A novel PEX14/PEX5 interface links peroxisomal protein import and receptor recycling

This paper identifies a novel PEX14/PEX5 interface involved in peroxisomal protein import and receptor recycling through biochemical and structural analysis.

Nuclear quality control of non-imported secretory proteins attenuates proteostasis decline in the cytosol

The paper identifies a nuclear quality control pathway that degrades mislocalized secretory proteins to prevent cytosolic proteostasis decline.

NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

This study identifies a NF-κB-independent role of NEMO in proteostasis by promoting aggrephagy through co-condensation with p62.

LUBAC assembles a signaling platform at mitochondria for signal amplification and shuttling of NF-ĸB to the nucleus

This study shows that LUBAC assembles at mitochondria to amplify and shuttle NF-κB signals to the nucleus during TNF activation.

Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

The paper shows that overexpressing Mia40 reduces toxic polyQ protein aggregates in yeast and human cells by competing for chaperone and proteasome resources.