Author

W. E. McIntire

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

M. D. Purdy· 2 shared M. Yeager· 2 shared S. A. Leonhardt· 2 shared A. A. Kossiakoff· 1 shared A. D. Finzi· 1 shared A. Rein· 1 shared B. C. Bennett· 1 shared D. A. Bayliss· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

M. D. Purdy

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2 papers

Recent·Most cited

CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter

S. A. Leonhardt, M. D. Purdy, J. R. Grover, Z. Yang, S. Poulos, W. E. McIntire, E. A. Tatham, S. Erramilli, K. Nosol, K. K. Lai, S. Ding, M. Lu, P. D. Uchil, A. D. Finzi, A. Rein, , M. Yeager

The paper shows SERINC3 has a structure similar to lipid transporters and demonstrates its lipid flipping activity, which correlates with reduced HIV-1 infectivity.

bioRxiv · Jul 6, 2022 · PreprintBiophysics

A Constitutively Closed Pannexin1 Channel in Lipid Bilayer Nanodiscs Assembles as a Large-Pore Heptamer

X. Jin, S. A. Leonhardt, Y.-H. Chiu, M. D. Purdy, W. E. McIntire, B. C. Bennett, D. A. Bayliss, M. Yeager

The paper examines a constitutively closed Panx1 channel, showing it assembles as a heptamer in solution and by cryoEM, with structural insights into large-pore channels.

bioRxiv · Dec 31, 2020 · PreprintBiophysics