Author

M. D. Purdy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Yeager· 4 shared S. A. Leonhardt· 2 shared W. E. McIntire· 2 shared A. A. Kossiakoff· 1 shared A. D. Finzi· 1 shared A. J. Pak· 1 shared A. Rein· 1 shared B. C. Bennett· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

M. Yeager

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4 papers

Recent·Most cited

CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter

S. A. Leonhardt, M. D. Purdy, J. R. Grover, Z. Yang, S. Poulos, W. E. McIntire, E. A. Tatham, S. Erramilli, K. Nosol, K. K. Lai, S. Ding, M. Lu, P. D. Uchil, A. D. Finzi, A. Rein, , M. Yeager

The paper shows SERINC3 has a structure similar to lipid transporters and demonstrates its lipid flipping activity, which correlates with reduced HIV-1 infectivity.

bioRxiv · Jul 6, 2022 · PreprintBiophysics

Preservation of HIV-1 Gag helical bundle symmetry by bevirimat is central tomaturation inhibition

A. J. Pak, M. D. Purdy, M. Yeager, G. A. Voth

This study uses molecular dynamics simulations to show that bevirimat's effectiveness against HIV-1 depends on preserving the six-helix bundle symmetry, with escape mutations causing symmetry loss.

bioRxiv · May 24, 2021Biophysics

A Constitutively Closed Pannexin1 Channel in Lipid Bilayer Nanodiscs Assembles as a Large-Pore Heptamer

X. Jin, S. A. Leonhardt, Y.-H. Chiu, M. D. Purdy, W. E. McIntire, B. C. Bennett, D. A. Bayliss, M. Yeager

The paper examines a constitutively closed Panx1 channel, showing it assembles as a heptamer in solution and by cryoEM, with structural insights into large-pore channels.

bioRxiv · Dec 31, 2020 · PreprintBiophysics

MicroED Structures of HIV-1 Gag CTD-SP1 Reveal Binding Interactions with the Maturation Inhibitor Bevirimat

M. D. Purdy, D. Shi, J. Chrustowicz, J. Hattne, T. Gonen, M. Yeager

The paper uses MicroED to determine the structure of HIV-1 Gag CTD-SP1 with bevirimat, revealing binding interactions that inform drug discovery.

bioRxiv · Dec 30, 2017Biophysics