ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling
A. von Kriegsheim, A. Bolado-Carrancio, M. Muir, A. Ewing, K. Macleod, W. Gallagher, L. Nguyen, N. O. Carragher, C. Semple, V. Brunton, P. Caswell
This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.
bioRxiv · Sep 12, 2019Cancer Biology