Author

K. Macleod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Muir· 2 shared N. O. Carragher· 2 shared V. Brunton· 2 shared A. Baig· 1 shared A. Bolado-Carrancio· 1 shared A. Ewing· 1 shared A. Grant· 1 shared A. J. Thompson· 1 shared

Activity by Year

2016-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

M. Muir

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors.

J. C. Dawson, A. Munro, K. Macleod, M. Muir, P. Timpson, R. Williams, M. C. Frame, V. Brunton, N. O. Carragher

This study profiles the effects of the SRC inhibitor AZD0424 in combination with MEK inhibitors, showing reduced compensatory activation and enhanced anti-tumor effects in colorectal cancer models.

bioRxiv · Aug 27, 2021 · PreprintCancer Biology

The ORGAN SIZE (ORG) locus contributes to isometric gigantism in domesticated tomato

M. H. Vicente, K. MacLeod, C. R. Figueiredo, A. V. Figueira, F. R. Mohareb, Z. Kevei, A. J. Thompson, A. Zsogon, L. Peres

The ORGAN SIZE (ORG) locus controls isometric size increase in vegetative and reproductive organs of tomato through changes in cell division.

bioRxiv · Apr 8, 2021 · PreprintPlant Biology

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

A. von Kriegsheim, A. Bolado-Carrancio, M. Muir, A. Ewing, K. Macleod, W. Gallagher, L. Nguyen, N. O. Carragher, C. Semple, V. Brunton, P. Caswell

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

bioRxiv · Sep 12, 2019Cancer Biology

Pathogenic potential of Hic1 expressing cardiac stromal progenitors

H. Soliman, B. Paylor, W. Scott, D. Lemos, C. Chang, M. Arostegui, M. Low, C. Lee, D. Fiore, P. Braghetta, V. Pospichalova, C. E. Barkauskas, V. Korinek, A. Rampazzo, K. MacLeod, , F. Rossi

This study identifies cardiac stromal progenitors as multipotent cells that contribute to fibrosis and arrhythmogenic cardiomyopathy under different pathological conditions.

bioRxiv · Feb 12, 2019Cell Biology

Genome-Wide Fitness Analyses of the Foodborne Pathogen Campylobacter jejuni in In Vitro and In Vivo Models

S. de Vries, S. Gupta, A. Baig, E. Wright, A. Wedley, A. Nygaard Jensen, L. LaCharme Lora, S. Humphrey, H. Skovgard, K. Macleod, E. Pont, D. Wolanska, J. L'Heureux, F. Mobegi, D. Smith, , A. Grant

This study identifies genes essential for Campylobacter jejuni growth and survival across multiple in vitro and in vivo conditions using transposon sequencing.

bioRxiv · Nov 5, 2016Microbiology