Author

V. Brunton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

M. Muir· 3 shared N. O. Carragher· 3 shared E. Bullock· 2 shared K. Macleod· 2 shared M. C. Frame· 2 shared A. Bolado-Carrancio· 1 shared A. Ewing· 1 shared A. Munro· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

M. Muir

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Author profile →

5 papers

Recent·Most cited

CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

J. M. Houthuijzen, R. de Bruijn, E. van der Burg, A. P. Drenth, E. Wientjens, T. Filipovic, E. Bullock, C. S. Brambillasca, M. Nieuwland, I. de Rink, F. van Diepen, S. Klarenbeek, R. Kerkhoven, V. Brunton, C. L. G. J. Scheele, , J. Jonkers

The paper identifies CD26-negative and CD26-positive tissue-resident fibroblasts as sources of distinct CAF subpopulations in breast cancer through single-cell transcriptomics and functional assays.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Loss of the adhesion protein Kindlin-1 stimulates tumor clearance via modulation of Tregs

E. Webb, G. Dodd, E. Bullock, M. Muir, M. C. Frame, A. Serrels, V. Brunton

This study shows that loss of Kindlin-1 in breast cancer cells reduces tumor growth by decreasing Treg numbers and function, mediated by increased IL-6 secretion.

bioRxiv · Mar 4, 2022Cancer Biology

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors.

J. C. Dawson, A. Munro, K. Macleod, M. Muir, P. Timpson, R. Williams, M. C. Frame, V. Brunton, N. O. Carragher

This study profiles the effects of the SRC inhibitor AZD0424 in combination with MEK inhibitors, showing reduced compensatory activation and enhanced anti-tumor effects in colorectal cancer models.

bioRxiv · Aug 27, 2021 · PreprintCancer Biology

Chemical-Genetic Interrogation of Nuclear Size Control Reveals Cancer-Specific Effects on Cell Migration and Invasion

A. Rizzotto, S. Tollis, N. T. Pham, J. Wildenhain, N. Zuleger, J. T. Keys, D. Batrakou, J. Culley, S. Zheng, J. Lammerding, N. O. Carragher, V. Brunton, M. Auer, M. Tyers, E. C. Schirmer

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

bioRxiv · Jan 10, 2020 · PreprintCancer Biology

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

A. von Kriegsheim, A. Bolado-Carrancio, M. Muir, A. Ewing, K. Macleod, W. Gallagher, L. Nguyen, N. O. Carragher, C. Semple, V. Brunton, P. Caswell

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

bioRxiv · Sep 12, 2019Cancer Biology