Author

W. K. Kim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Fumagalli· 1 shared A. Gusinac· 1 shared A. Sacchetti· 1 shared B. van der Steen· 1 shared B. Wainger· 1 shared B.-S. Han· 1 shared C. Hyeon· 1 shared D. Kim· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Fumagalli

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Author profile →

4 papers

Recent·Most cited

Kinetic model for the desensitization of G protein-coupled receptor

W. K. Kim, Y. Lee, S. J. Jang, C. Hyeon

The paper develops a kinetic model to understand GPCR desensitization by integrating biochemical steps from ligand binding to receptor internalization, identifying three downregulation regimes based on phosphorylation, dephosphorylation, and beta-arrestin levels.

bioRxiv · Apr 1, 2024Biophysics

Distinct modulation of calcium-activated chloride channel TMEM16A by a novel drug-binding site

J. W. Roh, H. Y. Gee, B. Wainger, W. K. Kim, W. Lee, J. H. Nam

The paper identifies a novel non-pore drug-binding site in TMEM16A using magnolol and honokiol, showing distinct inhibitory mechanisms through electrophysiology and molecular simulations.

bioRxiv · Aug 6, 2023 · PreprintPhysiology

Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism

M. Oh, S. Y. Jang, J.-Y. Lee, J. W. Kim, Y. Jung, J. Seo, T.-S. Han, E. Jang, H. Y. Son, D. Kim, M. W. Kim, K.-H. Song, K.-J. Oh, W. K. Kim, K.-H. Bae, , E.-W. Lee

This study shows that darapladib, an Lp-PLA2 inhibitor, enhances ferroptosis in cancer cells by altering lipid metabolism and synergizes with GPX4 inhibitors to suppress tumor growth.

bioRxiv · Apr 8, 2023 · PreprintCancer Biology

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

A. Sacchetti, M. Teeuwssen, M. Verhagen, R. Joosten, T. Xu, R. Stabile, B. van der Steen, M. M. Watson, A. Gusinac, W. K. Kim, I. Ubink, H. J. van de Werken, A. Fumagalli, M. Paauwe, J. van Rheenen, , R. Fodde

This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.

bioRxiv · Jul 24, 2020Cancer Biology