The role of positively charged small biomolecules in the aggregation of hyperphosphorylated tau in Alzheimer's disease
J. Lee, K. Lee, M. S. Kim, M. W. Kim, M. Lim, J. Yoo, S. H. Lee
This study identifies electrostatic interactions between hyperphosphorylated tau and polyamines as crucial for tau aggregation in Alzheimer's disease and observes the transition from aggregates to fibrils.
bioRxiv · Oct 19, 2023 · PreprintBiophysics