J. W. Kim

In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses

This study evaluates MIT-001's antiviral activity against SARS-CoV-2 and zoonotic viruses in vitro, showing inhibition of viral replication and restoration of antioxidant gene expression.

Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism

This study shows that darapladib, an Lp-PLA2 inhibitor, enhances ferroptosis in cancer cells by altering lipid metabolism and synergizes with GPX4 inhibitors to suppress tumor growth.

Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron variants

This study evaluates the antiviral efficacy of remdesivir, molnupiravir, and nirmatrelvir against newly emerged SARS-CoV-2 Omicron subvariants and finds they retain antiviral activity.

DLL3 REGULATES NOTCH SIGNALING IN SCLC

This study investigates DLL3's role in Notch signaling and SCLC heterogeneity, finding that high DLL3 levels promote a mixed neuroendocrine and non-neuroendocrine cell population.

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

This study compares the infectivity of SARS-CoV-2 variants in human alveolar cells, finding Omicron (BA.1) to be 3-5-fold more infectious than other variants at early infection.

The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression

This study identifies that the co-deletion of CIC and ERF leads to ETV1 activation, driving prostate cancer progression without fusion events.

Phenotypic and genotypic characterization of Listeria monocytogenes in clinical ruminant cases in Korea

This study characterizes the phenotypic and genotypic features of Listeria monocytogenes isolates from Korean ruminant clinical cases, revealing genetic diversity and antimicrobial resistance.

Optimal operation of parallel mini-bioreactors in bioprocess development using multi-stage MPC

This paper develops a multi-stage MPC strategy to optimize parallel mini-bioreactor operations under parametric uncertainties, improving experimental success rates.

Novel Paju Apodemus Paramyxovirus 1 and 2, Harbored by Apodemus agrarius in The Republic of Korea

This study identifies two novel paramyxoviruses, PAPV-1 and PAPV-2, from Apodemus agrarius rodents in Korea, revealing distinct genome structures and zoonotic potential.

Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation

The paper shows STRIPAK directs PP2A to dephosphorylate MAP4K4, promoting oncogenic transformation via YAP1 activation.

Modelling bistable tumour population dynamics to design effective treatment strategies

This study models bistable tumour population dynamics to evaluate treatment strategies, finding that periodic treatments outperform static ones and optimal control theory-based treatments are most effective.

Bacterial clearance enhanced by α2, 3- and α2, 6-sialyllactose via receptor-mediated endocytosis and phagocytosis

This study shows that sialyllactose enhances bacterial clearance in mice and human macrophages through receptor-mediated endocytosis, phagocytosis, and Rac1-mediated reactive oxygen species production.