Author

A. Belyy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 3 Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Raunser· 6 shared D. Roderer· 2 shared O. Hofnagel· 2 shared P. Bieling· 2 shared W. Oosterheert· 2 shared A. Roy· 1 shared B. Bardiaux· 1 shared B. U. Klink· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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6 shared papersBiochemistry

S. Raunser

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The impact of ligand-induced oligomer dissociation on enzyme diffusion, directly observed at the single-molecule level

Y. D. Yancheva, S. G. Kaya, A. Belyy, M. W. Fraaije, K. Tych

The paper investigates how ligand-induced oligomer dissociation affects enzyme diffusion using mass photometry, finding substrate-induced dissociation in some enzymes and not others.

bioRxiv · Jan 28, 2024Biophysics

Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

P. N. Ng`ang`a, J. Folz, S. Kucher, D. Roderer, Y. Xu, O. Sitsel, A. Belyy, D. Prumbaum, R. Kuehnemuth, T. E. Assafa, M. Dong, C. A. M. Seidel, E. Bordignon, S. Raunser

This study investigates the multi-state kinetics of Tc toxin prepore-to-pore transition, identifying intermediate states and transition times under various conditions.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Structure and activation mechanism of the Makes caterpillars floppy 1 toxin

A. Belyy, P. Heilen, P. Hagel, O. Hofnagel, S. Raunser

This study determines the cryo-EM structure of Mcf1 toxin and elucidates its activation mechanism through conformational changes and autocleavage.

bioRxiv · Aug 14, 2023Biochemistry

Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

W. Oosterheert, F. Blanc, A. Roy, A. Belyy, O. Hofnagel, G. Hummer, P. Bieling, S. Raunser

This study identifies a molecular backdoor mechanism for inorganic phosphate release from actin filaments, showing how a disease-linked mutation alters Pi release rates and filament structure.

bioRxiv · Mar 25, 2023Biochemistry

Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

A. Belyy, F. Lindemann, D. Roderer, J. Funk, B. Bardiaux, J. Protze, P. Bieling, H. Oschkinat, S. Raunser

This study reveals how TccC3 toxin modifies F-actin by ADP-ribosylating threonine-148, disrupting actin dynamics and causing cell death.

bioRxiv · May 6, 2022Biochemistry

Structural basis of actin filament assembly and aging

W. Oosterheert, B. U. Klink, A. Belyy, S. Pospich, S. Raunser

This study presents cryo-EM structures of F-actin in all nucleotide states, revealing how water molecules drive ATP hydrolysis and filament dynamics, and explains differences in polymerization rates between Ca2+ and Mg2+-actin.

bioRxiv · Mar 29, 2022Biochemistry

Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens

A. Belyy, F. Merino, U. Mechold, S. Raunser

The paper investigates how actin interacts with nucleotidyl cyclase toxins from bacterial pathogens to activate them, revealing structural changes and allosteric mechanisms.

bioRxiv · Jun 27, 2021Biochemistry