W. R. Thompson

Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running

This study shows that disrupting the LINC complex in bone progenitor cells reduces exercise-induced osteoid deposition but not bone quality in mice.

Osterix-driven LINC complex disruption in vivo diminishes bone microarchitecture in 8-week male mice but not after 6-week voluntary wheel running

This study examines the effect of Osterix-driven LINC complex disruption on bone microarchitecture in mice, finding reduced bone quality at 8 weeks but no significant change after 6 weeks of voluntary running.

Low-Magnitude Mechanical Signals Combined with Zoledronic Acid Reduce Musculoskeletal Weakness and Adiposity in Estrogen-Deprived Mice

Combining low-intensity vibration with zoledronic acid reduces musculoskeletal weakness and adiposity in estrogen-deprived mice.

Single Cell Cortical Bone Transcriptomics Defines Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease

The paper defines novel osteolineage gene sets using single-cell transcriptomics and identifies molecular defects in a CKD mouse model.

Generation of two Multipotent Mesenchymal Progenitor Cell Lines Capable of Osteogenic, Mature Osteocyte, Adipogenic, and Chondrogenic Differentiation

The paper develops two mesenchymal progenitor cell lines that can differentiate into osteogenic, adipogenic, and chondrogenic lineages and mimic in vivo responses of key regulatory genes.

Mechanical Suppression of Breast Cancer Cell Invasion and Paracrine Signaling Requires Nucleo-Cytoskeletal Connectivity

This study shows that low-intensity vibration reduces breast cancer cell invasion and osteolytic factor secretion by mechanosensory nuclear-cytoskeletal connectivity.