W. Tan

This study shows that monoubiquitination of FANCD2 stabilizes the FANCI:FANCD2 complex on DNA and forms filamentous arrays, revealing a mechanism for DNA repair pathway activation.

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

This study shows that all three Tad operons in Vibrio vulnificus are required for pathogenicity, as they enable host invasion, survival in blood, and resistance to complement activation through Flp pili.

This study characterizes age-related morphological changes in carotid and cerebral arteries of sickle cell anemia mice using ultrasound and micro-CT, finding increased arterial dimensions and narrowing in SS mice.

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.