Author

W. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:protein structure prediction· 2 Organism:virus· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. F. Haynes· 5 shared K. Janowska· 4 shared K. O. Saunders· 4 shared M. Deyton· 4 shared P. Acharya· 4 shared R. Henderson· 4 shared R. J. Edwards· 4 shared R. Parks· 4 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

B. F. Haynes

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

V. Stalls, J. Lindenberger, S. Gobeil, R. Henderson, R. Parks, M. Barr, M. Deyton, M. Martin, K. Janowska, X. Huang, A. May, M. Speakman, E. Beaudoin, B. Kraft, X. Lu, , P. Acharya

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

bioRxiv · Apr 7, 2022Biochemistry

Structural diversity of the SARS-CoV-2 Omicron spike

S. Gobeil, R. Henderson, V. Stalls, K. Janowska, X. Huang, A. May, M. Speakman, E. Beaudoin, K. Manne, D. Li, R. Parks, M. Barr, M. Deyton, M. Martin, K. Mansouri, , P. Acharya

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

bioRxiv · Jan 25, 2022Biochemistry

Cold sensitivity of the SARS-CoV-2 spike ectodomain

R. J. Edwards, K. Mansouri, V. Stalls, K. Manne, B. Watts, R. Parks, K. Janowska, S. M. C. Gobeil, M. Kopp, D. Li, X. Lu, Z. Mu, M. Deyton, T. Oguin, J. Sprenz, , P. Acharya

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

bioRxiv · Jul 12, 2020Biochemistry

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

P. Acharya, W. Williams, R. Henderson, K. Janowska, K. Manne, R. Parks, M. Deyton, J. Sprenz, V. Stalls, M. Kopp, K. Mansouri, R. J. Edwards, R. Meyerhoff, T. Oguin, G. Sempowski, , B. F. Haynes

The paper shows that HIV-1 broadly neutralizing antibodies recognize a glycan cluster on the SARS-CoV-2 spike protein, revealing a potential target for vaccine design.

bioRxiv · Jun 30, 2020 · PreprintImmunology

Fractional re-distribution among cell motility states during ageing

J. M. Phillip, N. Zamponi, M. P. Phillip, J. Daya, S. McGovern, W. Williams, K. Tschudi, H. Jayatilaka, P.-H. Wu, J. Walston, D. Wirtz

The paper shows that ageing reduces cell motility heterogeneity by redistributing cells among motility states rather than uniformly decreasing motility.

bioRxiv · Apr 29, 2020Bioengineering

Genomic evidence for the degradation of terrestrial organic matter by pelagic Arctic Ocean Chloroflexi bacteria

D. Colatriano, P. Tran, C. Gueguen, W. Williams, C. Lovejoy, D. Walsh

The paper identifies aromatic compound degradation genes in Arctic Ocean Chloroflexi bacteria, suggesting they can utilize terrestrial organic matter and may play a growing role in the carbon cycle.

bioRxiv · May 17, 2018Microbiology

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody Development

K. Wiehe, T. Bradley, R. R. Meyerhoff, C. Hart, W. Williams, D. Easterhoff, W. J. Faison, T. B. Kepler, K. O. Saunders, S. M. Alam, M. Bonsignori, B. F. Haynes

The paper identifies improbable mutations critical for HIV broadly neutralizing antibody development and proposes a mutation-guided vaccine strategy.

bioRxiv · Feb 9, 2018Immunology