C. Hart

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Comparative pathogenesis of two lineages of Powassan virus reveals distinct clinical outcome, neuropathology, and inflammation.

This study compares two Powassan virus lineages in mice, showing distinct CNS infection patterns, immune responses, and clinical outcomes.

Human Rhinoviruses: a novel class of oncolytic virus

This study investigates wild-type human rhinoviruses (HRVs) as oncolytic viruses, showing their ability to kill cancer cells and induce tumor regression in vitro and in vivo.

IRF7 impacts on prostate cancer cell survival in response to radiation

This study investigates how IRF7 influences prostate cancer cell survival after radiation and identifies therapeutic vulnerabilities linked to IRF7 expression.

Human Galectin-9 Promotes the Expansion of HIV Reservoirs in vivo in Humanized Mice

This study shows that Gal-9 treatment during ART increases HIV DNA and RNA in tissues of humanized mice, suggesting it promotes HIV persistence.

Active Rheumatoid Arthritis in a Mouse Model is not an Independent Risk Factor for Periprosthetic Joint Infection

This study investigates whether active rheumatoid arthritis in a mouse model affects periprosthetic joint infection risk, finding no significant difference in bacterial burden between RA and control mice.

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody Development

The paper identifies improbable mutations critical for HIV broadly neutralizing antibody development and proposes a mutation-guided vaccine strategy.