Author

G. Sempowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

K. Manne· 2 shared K. Mansouri· 2 shared K. O. Saunders· 2 shared P. Acharya· 2 shared R. J. Edwards· 2 shared R. Parks· 2 shared X. Shen· 2 shared A. Begum· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

K. Manne

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

D. Martinez, A. Schaefer, S. Gobeil, D. Li, G. De la Cruz, R. Parks, X. Lu, M. Barr, K. Manne, K. Mansouri, R. J. Edwards, B. Yount, K. Anasti, S. Montgomery, X. Shen, , R. S. Baric

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

bioRxiv · Apr 27, 2021 · PreprintMicrobiology

The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae

I. Leduc, K. L. Connolly, A. Begum, K. Underwood, N. Rahman, s. Darnell, J. Balthazar, w. shafer, A. N. Macintyre, g. sempowski, A. Jerse

This paper demonstrates that the 4CMenB vaccine, based on Neisseria meningitidis outer membrane vesicles, provides cross-species protection against Neisseria gonorrhoeae in a mouse model, with antibodies targeting several surface proteins.

PLOS Pathogens · Dec 8, 2020Peer-reviewedMicrobiology

Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19

C. Yu, S. Littleton, N. Giroux, R. Mathew, S. Ding, J. Kalnitsky, E. Petzold, H. Chung, G. r. Palomino, T. Rotstein, R. Xi, E. R. Ko, E. L. Tsalik, g. sempowski, T. N. Denny, , D. R. Saban

The paper examines sex differences in MAIT cell responses in COVID-19 patients, finding reduced circulating MAIT cells in females and a protective gene signature associated with female MAIT cells.

bioRxiv · Dec 1, 2020Immunology

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

P. Acharya, W. Williams, R. Henderson, K. Janowska, K. Manne, R. Parks, M. Deyton, J. Sprenz, V. Stalls, M. Kopp, K. Mansouri, R. J. Edwards, R. Meyerhoff, T. Oguin, G. Sempowski, , B. F. Haynes

The paper shows that HIV-1 broadly neutralizing antibodies recognize a glycan cluster on the SARS-CoV-2 spike protein, revealing a potential target for vaccine design.

bioRxiv · Jun 30, 2020 · PreprintImmunology

Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam

T. T. Lam, D. Toffaletti, J. Tenor, C. Giamberardino, G. Sempowski, Y. Asfaw, T. H. Phan, A. V. Duong, T. M. Nguyen, L. P. H. Nguyen, C. T. H. Tran, P. M. Ashton, J. Beardsley, C. V. V. Nguyen, G. E. Thwaites, , J. N. Day

This study compares the virulence of Cryptococcus neoformans ST5 and non-ST5 isolates in HIV-infected and uninfected patients in Vietnam, finding ST5 isolates show greater variability and initial inflammatory response but lower fungal burden in mice.

bioRxiv · Feb 19, 2020Microbiology