K. Mansouri

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes

This study designs engineered immunogens targeting conserved coronavirus epitopes to elicit broad-spectrum antibodies, showing protection in mice against live virus challenge.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

Structural diversity of the SARS-CoV-2 Omicron spike

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

Protective transfer: Maternal passive immunization with a rotavirus-neutralizing dimeric IgA protects against rotavirus disease in suckling neonates

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity

This study examines how mutations in SARS-CoV-2 spike protein affect its structure, conformation, and antigenicity across variants from different origins.

SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys

This study shows that SARS-CoV-2 vaccines induce neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, and batCoVs in monkeys.

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction

This study shows the D614G mutation in SARS-CoV-2 spike protein increases furin cleavage efficiency and alters RBD dynamics through allosteric effects.

Cold sensitivity of the SARS-CoV-2 spike ectodomain

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

The paper shows that HIV-1 broadly neutralizing antibodies recognize a glycan cluster on the SARS-CoV-2 spike protein, revealing a potential target for vaccine design.

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation

The paper shows glycans on SARS-CoV-2 Spike influence RBD conformational states, affecting antibody neutralization and vaccine design.

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation

The paper analyzes SARS-CoV-2 spike protein conformations and develops engineered constructs to control its mobility for vaccine design.