R. Cao

Spatiotemporal regulation of Pseudorabies Virus Thymidine kinase UL23 by post-translational modification

This study investigates SUMO modification of PRV UL23 and shows it affects subcellular localization but not stability.

Structural Requirements for Activity of Mind bomb1 in Notch Signaling

This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.

Genome-wide CRISPR screen identifies AC9 as a key regulator of ER calcium homeostasis involved in neuronal differentiation.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

Neural space-time model for dynamic scene recovery in multi-shot computational imaging systems

The paper introduces a neural space-time model to recover dynamic scenes in multi-shot computational imaging systems by jointly estimating the scene and its motion, reducing motion artifacts.

Task-Dependent Representation of Features Binding within the Same Dimension in Visual Working Memory

The paper investigates how task demands affect the storage format of features in visual working memory, finding that performance depends on feature count and conjunction probe frequency.

High-speed Auto-Polarization Synchronization Modulation Three-dimensional Structured Illumination Microscopy

This paper introduces a high-speed 3DSIM system using DMD and electro-optic modulators, achieving improved resolution and imaging speed for various biological specimens.

Honey varietals differentially impact Bifidobacterium animalis ssp lactis survivability in yogurt through simulated in vitro digestion

This study evaluates how different honey varietals and concentrations affect the survival of B. animalis in yogurt during in vitro digestion, finding that clover honey at 10-20% w/w significantly improves probiotic survivability.

Molecular Mechanism of PP2A/B55α Phosphatase Inhibition by IER5

This study determines the structure of PP2A/B55 inhibited by IER5-N50 and shows its role in suppressing pTau dephosphorylation and KRT1 expression.

Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

Open-3DSIM: an Open-source three-dimensional structured illumination microscopy reconstruction platform

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

Japanese Encephalitis Virus NS1 Protein regulates the expression and distribution of TIM-1 to promote viral infection

This study shows that JEV NS1 protein increases TIM-1 expression and shifts its distribution to the cytoplasm, enhancing viral infection by reducing TIM-1-mediated restriction.

Photoacoustic imaging reveals transient decrease of oxygenation in murine blood due to monoclonal IgG4 antibody

The paper uses photoacoustic imaging to show that a monoclonal IgG4 antibody reduces local blood oxygen saturation in mice without affecting total hemoglobin or oxygen extraction fraction.

An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arrays

This paper introduces an automated workflow for generating and analyzing 3D tumor-mimetic microtissues using the SPOT platform, enabling high-throughput screening and single-cell analysis of patient-derived organoids.

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

This paper introduces a high-throughput platform for generating standardized organoid microtissues to enable drug screening and phenotypic assays.

Rational evolution of a recombinant DNA polymerase for efficient incorporation of unnatural nucleotides by dual-site boosting

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

Targeted degradation of the oncogenic phosphatase SHP2

This paper develops a SHP2 PROTAC that degrades SHP2 in leukemic cells, inhibits MAPK signaling, and suppresses cancer growth.

A non-coding A-to-T Kozak site change related to the transmissibility of Alpha, Delta and Omicron VOCs

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

Unbalanced dietary patterns contribute to the pathogenesis of precocious puberty by affecting gut microbiota and host metabolites

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

An interactive viral genome evolution network analysis system enabling rapid large-scale molecular tracing of SARS-CoV-2

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

MicroRNA-1 promotes the development of and prolongs engorgement time in Hyalomma anatolicum anatolicum (Acari: Ixodidae) ticks

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

Proinflammatory S100A9 Regulate Differentiation and Aggregation of Neural Stem Cells

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis

The paper analyzes the Human Protein Atlas database to identify potential key molecules in the airway epithelial cell microenvironment that may facilitate SARS-CoV-2 entry and immune response activation.

The pathognomonic FOXL2 C134W mutation alters DNA binding specificity

This study investigates the molecular effects of the FOXL2 C134W mutation in AGCT by analyzing DNA binding and transcriptome changes in engineered cell lines.

A transferrable and interpretable multiple instance learning model for microsatellite instability prediction based on histopathology images

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

Computationally guided high-throughput design of self-assembling drug nanoparticles

This paper develops a high-throughput screening platform with machine learning to design self-assembling drug nanoparticles, identifying 101 novel formulations from 2.1 million combinations.

Characterizing the Effects of Glutathione as an Immunoadjuvant in the Treatment of Tuberculosis

This study investigates the synergistic effects of NAC and first-line TB antibiotics on macrophage control of M. tb infection, finding enhanced immunomodulation and reduced bacterial viability.