Author

R. Voleti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

N. H. Shah· 2 shared A. E. van Vlimmeren· 1 shared A. J. Groffen· 1 shared A. Li· 1 shared C. A. Chartier· 1 shared D. Gagoski· 1 shared D. Karandur· 1 shared E. Kerklingh· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

N. H. Shah

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Author profile →

3 papers

Recent·Most cited

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain

A. E. van Vlimmeren, R. Voleti, C. A. Chartier, Z. Jiang, D. Karandur, P. A. Humphries, W.-L. Lo, N. H. Shah

This paper investigates the T42A mutation in SHP2, showing it alters ligand-binding specificity in the N-terminal SH2 domain, leading to biased activation and enhanced signaling.

bioRxiv · Jul 10, 2023Biochemistry

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

A. Li, R. Voleti, M. Lee, D. Gagoski, N. H. Shah

This paper develops a platform to quantitatively profile sequence recognition by tyrosine kinases and SH2 domains using peptide libraries and deep sequencing, revealing phosphosite-specific mutations and binding affinities.

bioRxiv · Aug 1, 2022Biochemistry

Synaptotagmin-1 and Doc2b exhibit distinct membrane remodeling mechanisms

R. Sorkin, M. Marchetti, E. Logtenberg, M. Piontek, E. Kerklingh, G. Brand, R. Voleti, J. Rizo, W. H. Roos, A. J. Groffen, G. J. L. Wuite

This study compares how Synaptotagmin-1 and Doc2b remodel membranes through different mechanisms, revealing distinct roles in Ca2+-triggered secretion.

bioRxiv · Feb 1, 2019Biophysics