Author

W.-P. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

C. Tang· 4 shared Z. Gong· 3 shared H.-W. Yi· 2 shared J. Yang· 2 shared T.-F. Wei· 2 shared X. Dong· 2 shared Y.-B. Lu· 2 shared B. Moore· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

C. Tang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain

C. Chen, H.-W. Yi, Y. Zhang, T. Wang, T.-Y. Gao, Z.-L. Lou, T.-F. Wei, Y.-B. Lu, T.-T. Li, W.-P. Zhang, C. Tang

This study shows that phosphorylated ubiquitin (pUb) increases with age and contributes to neurodegeneration by impairing proteasomal function and accelerating protein aggregation.

bioRxiv · Aug 10, 2023 · PreprintCell Biology

Uncovering Ghost Introgression Through Genomic Analysis of a Distinct East Asian Hickory Species

W.-P. Zhang, Y.-M. Ding, Y. Cao, P. Li, Y. Yang, X.-X. Pang, W.-N. Bai, D.-Y. Zhang

The paper detects ghost introgression in Carya sinensis using genomic analysis and phylogenetic methods, revealing introgression from an extinct lineage.

bioRxiv · Jun 26, 2023 · PreprintEvolutionary Biology

PP2A forestalls mitophagy by dephosphorylating Parkin and ubiquitin

S.-X. Ye, X.-Y. Liu, Z.-F. Nie, L.-S. Meng, X. Dong, F.-F. Li, Z. Gong, W. Yang, W.-P. Zhang, C. Tang

This study identifies PP2A as a phosphatase that dephosphorylates Parkin and ubiquitin, thereby inhibiting mitophagy.

bioRxiv · Mar 12, 2022 · PreprintBiochemistry

A key interfacial residue identified with in-cell structure characterization of a Class-A GPCR dimer

W.-P. Zhang, J. Yang, Z. Gong, Y.-B. Lu, C.-J. Xu, T.-F. Wei, M.-S. Yang, T.-W. Zhan, Y.-H. Yang, L. Li, J.-F. Liu, C. Tang

The paper identifies a key residue in a GPCR dimer using in-cell structure characterization and shows its impact on dimerization and signaling.

bioRxiv · Jun 7, 2019 · PreprintBiochemistry

Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13

Z. Liu, X. Dong, H.-W. Yi, J. Yang, Z. Gong, Y. Wang, K. Liu, W.-P. Zhang, C. Tang

This paper determines the structural basis of how Rpn13 recognizes K48-linked Ub chains through a bivalent interaction, revealing a mechanism for proteasomal selectivity.

bioRxiv · Jan 29, 2019Biophysics

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

Z.-R. Li, J. Li, W. Cai, J. Lai, S. McKinnie, W.-P. Zhang, B. Moore, W. Zhang, P.-Y. Qian

This study identifies colibactin-645 as a genotoxic metabolite that induces DNA double-strand breaks via a copper-mediated oxidative mechanism, revealing its role in colorectal cancer progression.

bioRxiv · Jan 24, 2019Microbiology