Structural rearrangements of a caspase-like protease TPR-CHAT govern virus-host discrimination during type III-E CRISPR-Caspase immunity
N. Cui, J.-T. Zhang, Z. Li, X.-Y. Liu, C. Wang, H. Huang, N. Jia
The paper reports cryo-EM structures of gRAMP-crRNA and gRAMP-crRNA-TPR-CHAT complexes, revealing how TPR-CHAT discriminates between self and non-self RNA targets through conformational changes.
bioRxiv · Sep 3, 2022Biochemistry