KDM5A/B promotes HIV-1 latency and KDM5 inhibitors promote HIV-1 lytic reactivation
T.-W. Li, D. Zhou, Z. Wu, G. N. Fiches, X. Wang, Y. Park, W. Jiang, W.-Z. Ho, A. D. Badley, N. G. Santoso, J. Qi, J. Zhu
This study shows that KDM5A/B promote HIV-1 latency and their inhibition with JQKD82, combined with AZD5582, reactivates HIV-1 and induces cell death.
bioRxiv · Nov 17, 2022 · PreprintMicrobiology