Author

G. N. Fiches

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

D. Zhou· 4 shared J. Zhu· 4 shared A. Biswas· 3 shared N. G. Santoso· 3 shared T.-W. Li· 2 shared Z. Wu· 2 shared A. D. Badley· 1 shared A. D. Kenney· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMicrobiology

D. Zhou

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

KDM5A/B promotes HIV-1 latency and KDM5 inhibitors promote HIV-1 lytic reactivation

T.-W. Li, D. Zhou, Z. Wu, G. N. Fiches, X. Wang, Y. Park, W. Jiang, W.-Z. Ho, A. D. Badley, N. G. Santoso, J. Qi, J. Zhu

This study shows that KDM5A/B promote HIV-1 latency and their inhibition with JQKD82, combined with AZD5582, reactivates HIV-1 and induces cell death.

bioRxiv · Nov 17, 2022 · PreprintMicrobiology

SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation

T.-W. Li, A. D. Kenney, H. Liu, G. N. Fiches, D. Zhou, A. Biswas, J. Que, N. Santoso, J. S. Yount, J. Zhu

This study shows that SARS-CoV-2 Nsp14 activates NF-κB signaling and increases IL-8 expression, which is confirmed in infected cells and lung tissue from COVID-19 patients.

bioRxiv · May 26, 2021 · PreprintMicrobiology

Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection

G. N. Fiches, A. Biswas, D. Zhou, W. Kong, M. Jean, N. G. Santoso, J. Zhu

This study shows that KSHV modulates polyamine biosynthesis and eIF5A hypusination to promote viral infection and oncogenesis, identifying these pathways as therapeutic targets.

bioRxiv · Dec 19, 2020Microbiology

Inhibition of polo-like kinase 1 (PLK1) facilitates reactivation of gamma-herpesviruses in B-cell lymphomas and their elimination

A. Biswas, G. N. Fiches, D. Zhou, Z. Wu, X. Liu, Q. Ma, W. Zhao, J. Zhu, N. G. Santoso

This study shows that inhibiting PLK1 promotes reactivation of KSHV and EBV in B-cell lymphomas, leading to cell death, and identifies PLK1 as a potential therapeutic target for HIV-positive patients.

bioRxiv · Oct 8, 2020 · PreprintCancer Biology