A. I. Khan

Diversity of Vibrio cholerae O1 through the human gastrointestinal tract during cholera

This study compares genetic diversity of Vibrio cholerae O1 in vomit and stool from cholera patients, finding reduced diversity in stool and some gene loss between samples.

Phage predation, disease severity and pathogen genetic diversity in cholera patients

A study of cholera patients in Bangladesh identifies phage predation as a biomarker of disease severity and driver of coevolution within patients.

Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting

This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.

Development of a monoclonal antibody to a vibriophage as a proxy for Vibrio cholerae detection

This study develops a monoclonal antibody to the vibriophage ICP1 to improve cholera detection in rapid diagnostic tests by detecting the phage as a proxy for Vibrio cholerae.

Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens

This study links gut bacteria-derived sphingolipids to enhanced innate immune responses to an oral cholera vaccine using metagenomic and experimental approaches.

A combination of metagenomic and cultivation approaches reveals hypermutator phenotypes within Vibrio cholerae infected patients

The paper combines metagenomics and cultivation approaches to show V. cholerae hypermutator phenotypes in infected patients, with evidence of adaptive mutations and transversion mutations.

Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions

This study shows that antimicrobial resistance in Vibrio cholerae increases under anaerobic conditions and identifies distinct genetic factors associated with resistance in these conditions.

Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants

This study examines the correlation between vaccine-induced IgG levels and neutralizing titers against SARS-CoV-2 and its variants, finding a significant positive correlation and reduced neutralization against variants.

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

Predicting Vibrio cholerae infection and disease severity using metagenomics in a prospective cohort study

This study uses metagenomic sequencing to predict cholera infection and disease severity in a cohort, identifying protective bacterial species and genes.

Different features of cholera in malnourished and non-malnourised children: analysis of 10-year surveillance data from a large diarrheal disease hospital in urban Bangladesh

This study compares clinical features of cholera in malnourished and non-malnourished children using surveillance data from Bangladesh, finding differences in presentation and hospitalization.

Cognate T and B cell interaction and association of Follicular helper T cells with B cell responses in Vibrio cholerae O1 infected Bangladeshi adults

This study investigates the role of follicular helper T (Tfh) cells in B cell responses during Vibrio cholerae O1 infection, finding that Tfh cells expressing CD40L are associated with memory B cell responses and antibody class switching.

Vibrio cholerae genomic diversity within and between patients

This study examines V. cholerae genomic diversity within and between patients, finding limited point mutations but higher gene content variation, including phage and plasmid exchanges, which may impact disease outcomes.