Copper-Containing ROS-Scavenging Nanozyme Paradoxically Drives Alpha-Synucleinopathy by Amplifying Nitrosative Stress
Shuya Li, Yuanyang Mao, Ning Wang, Jiawei Zhang, Xinpeng Zhi, Yuyang Chen, Jingjing Si, Yang Qi, Ramhari Kumbhar, Deok Joeng, Ji-Yang Song, Xiuli Yang, Bong Gu Kang, Anika Khandekar, Janis Park, , Xiaobo Mao
The paper shows a copper-containing nanozyme worsens alpha-synucleinopathy by increasing nitrosative stress, while a copper-free version reduces pathology in neurodegenerative models.
bioRxiv · Jul 1, 2025 · PreprintPathology