Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia
Weixing Shen, Shenyu Zhai, Veronica Francardo, Qiaoling Cui, Linqing Sun, Zhong Xie, Tatiana Tkatch, Valeria Estrada Corredor, Edward S. Lein, Jonathan T. Ting, Maria Angela Cenci, D. James Surmeier
This study identifies GluN2B-containing NMDAR up-regulation in iSPNs as a key mechanism in LID, showing that targeting these receptors can reduce dyskinesia without affecting levodopa's motor benefits.
Neuron · May 4, 2026Peer-reviewedNeuroscience