Maria Angela Cenci

This study shows that activating pyramidal tract neurons in the motor cortex reduces pathological dopaminergic motor responses in mice with Parkinson's-like symptoms.

This study identifies GluN2B-containing NMDAR up-regulation in iSPNs as a key mechanism in LID, showing that targeting these receptors can reduce dyskinesia without affecting levodopa's motor benefits.

The paper identifies two main dyskinesia types and pathological rotations in a mouse model of LID using high-resolution motion sensors and video recordings, linking them to abnormal activity in specific striatal SPN ensembles.