Shenyu Zhai

Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia

This study identifies GluN2B-containing NMDAR up-regulation in iSPNs as a key mechanism in LID, showing that targeting these receptors can reduce dyskinesia without affecting levodopa's motor benefits.

State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease

This study identifies state-dependent modulation of spiny projection neurons in a mouse Parkinson's model and shows how disrupting specific signaling pathways reduces levodopa-induced dyskinesia.

Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.