NeuroscienceNeuronPeer-reviewed
Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia
Weixing Shen, Shenyu Zhai, Veronica Francardo…·D. James Surmeier
This study identifies GluN2B-containing NMDAR up-regulation in iSPNs as a key mechanism in LID, showing that targeting these receptors can reduce dyskinesia without affecting levodopa's motor benefits.
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