Author

Wen Hu

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biochemistry· 2 Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Guan Wang· 2 shared H. Eric XuiD· 2 shared Jiankui HeiD· 2 shared Li Qin· 2 shared Luwen Ning· 2 shared Meng Zhang· 2 shared Pinghua Liu· 2 shared Qingming Hou· 2 shared

Activity by Year

2014-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenomics

Guan Wang

Mutual co-authors in cluster

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5 papers

Recent·Most cited

β-arrestin1 directly engages Gαs to sustain endosomal GPCR signaling

Qian He, Qingning Yuan, XiHeng HE, Wen Hu, H. Eric Xu, Lihua Zhao

This study shows β-arrestin1 directly binds Gαs to sustain endosomal GPCR signaling by stabilizing Gs in a signaling-competent state.

bioRxiv · Sep 28, 2026 · PreprintBiochemistry

Molecular principles for graded activation of dopamine D1 receptor

Xinyue Zhang, Yu Zheng, Heng Liu, Jingjing Hou, Luyu Fan, Xinheng He, Jun Sun, Tao Liu, Jianhui Zhou, Ruxin Lei, Mingyang Li, Wen Hu, Xi Cheng, Sheng Wang, Xin Xie, , Youwen Zhuang

The paper defines the molecular mechanism of graded activation of the dopamine D1 receptor and shows how ligand efficacy is encoded through an activation pathway.

bioRxiv · Jul 29, 2026 · PreprintBiochemistry

YIPPEE/YPEL5 regulates circadian period by modulating PER ubiquitination and stability

Meilin Li, Yue Zhou, Huihui Huang, Mengmeng Ren, Wen Hu, Xianhui Liu, Yong Zhang

This study identifies YIPPEE/YPEL5 as a conserved regulator of circadian rhythms by modulating PER/PER2 ubiquitination and stability, affecting circadian period length.

bioRxiv · Apr 30, 2026 · PreprintMolecular Biology

Quantitative comparison of single-cell sequencing methods using hippocampal neurons

Luwen Ning, Guan Wang, Zhoufang Li, Wen Hu, Qingming Hou, Yin Tong, Meng Zhang, Li Qin, Xiaoping Chen, Heng-Ye Man, Pinghua Liu, Jiankui He

This study compares three single-cell DNA amplification methods in hippocampal neurons, finding MALBAC and WGA4 to be highly reproducible with high success rates and ability to detect copy number variations.

bioRxiv · Apr 21, 2014 · PreprintGenomics

Quantitative comparison of single-cell sequencing methods using hippocampal neurons

Luwen Ning, Guan Wang, Zhoufang Li, Wen Hu, Qingming Hou, Yin Tong, Meng Zhang, Li Qin, Xiaoping Chen, Hengye Man, Pinghua Liu, Jiankui He

This study compares three single-cell DNA amplification methods in hippocampal neurons, finding MALBAC and WGA4 to be highly reproducible with high success rates and ability to detect copy number variations.

bioRxiv · Apr 18, 2014 · PreprintGenomics