Sheng Wang

The S1B-Targeting PEDV Neutralizing Antibody C62 Prematurely Activates S-trimer and Mimics Receptor Function

This study determines the structure of PEDV S1B bound by neutralizing and non-neutralizing antibodies, revealing how C62 targets a conserved epitope and influences viral entry and neutralization.

Molecular principles for graded activation of dopamine D1 receptor

The paper defines the molecular mechanism of graded activation of the dopamine D1 receptor and shows how ligand efficacy is encoded through an activation pathway.

Genetic score omics regression and multi-trait meta-analysis detect widespread cis-regulatory effects shaping bovine complex traits

GSOR and MTAO detect widespread cis-regulatory effects on bovine complex traits by linking gene expression with genetic scores and multi-trait associations.

Toward De Novo Protein Design from Natural Language

This paper introduces Pinal, a foundation model that designs proteins from natural language descriptions, achieving functional alignment and experimental success in four design tasks.

An efficient error correction and accurate assembly tool for noisy long reads

NextDenovo corrects noisy Nanopore reads faster and more accurately than Canu and Necat; its maize and 35 human-genome assemblies are more contiguous, with fewer misassemblies, than Flye's.

Periodic spatial patterning with a single morphogen

The paper demonstrates that a single morphogen with an intracellular positive feedback loop can generate stable, long-range spatial patterns through a Turing mechanism.

Weak-Instrument Robust Tests in Two-Sample Summary-Data Mendelian Randomization

This paper introduces robust statistical tests for two-sample summary-data Mendelian randomization that control Type I error and improve power under weak instruments.