Fusobacterium nucleatum produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis
Kyoung‐Jae Won, Pei-Ru Jin, Lydia Davis, Jimmy Orjala, Abigail T. Armstrong, Wen- Hung Wang, Harish Kothandaraman, Sagar M. Utturkar, Dawon Bae, Byeong‐Seon Jeong, Chenggang Wu, Iain A. Murray, Gary H. Perdew, Chijian Xiang, Jianing Li, , Hyunyoung Jeong
This study identifies Fusobacterium nucleatum-produced indole metabolites that activate the AHR-TERT axis, promoting CRC cell proliferation and revealing FTIN as a potential biomarker.
bioRxiv · Sep 25, 2025 · PreprintMicrobiology