Harish Kothandaraman

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a-deficient mice

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

Immune dysregulation in the prostates of C57BL/6Aire-/- mice mirrors that seen in human benign prostatic hyperplasia

This paper develops a mouse model of chronic prostatic inflammation that mirrors human BPH by showing similar immune and fibroblast features identified through scRNA-seq.

Fusobacterium nucleatum produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis

This study identifies Fusobacterium nucleatum-produced indole metabolites that activate the AHR-TERT axis, promoting CRC cell proliferation and revealing FTIN as a potential biomarker.

Activation of PP2A-B56α leads to aberrant EGFR signaling and proliferative phenotypes in PDAC

This study shows that activating PP2A-B56 in PDAC increases EGFR signaling and promotes tumor growth, suggesting a new therapeutic target.

Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

The paper links an age-associated CD8+ T cell subset to symptomatic benign prostatic hyperplasia through immune aging mechanisms.

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

Infiltrating lipid-rich macrophage subpopulations identified as a regulator of increasing prostate size in human benign prostatic hyperplasia

The paper identifies lipid-rich macrophage subpopulations in BPH that correlate with prostate size and urinary symptoms.

First near complete haplotype phased genome assembly of River buffalo (Bubalus bubalis)

This paper presents the first haplotype-phased genome assembly of river buffalo using a trio sequencing approach, achieving high-quality scaffolding and chromosome-level assembly.

The Cuon Enigma: Genome survey and comparative genomics of the endangered Dhole (Cuon alpinus)

The paper presents the first high-coverage genome survey of the endangered dhole and compares it with African wild dog, dingo, and domestic dog to identify structural variants and genes associated with unique traits.

High coverage genome sequencing and identification of genomic variants in Bengal tiger (Panthera tigris tigris)

The paper reports high coverage genome sequencing of the Bengal tiger and identifies genomic variants compared to the Amur tiger genome.