Spatial organization of the 3D genome encodes gene co-expression programs in single cells
Peng Dong, Shu Zhang, Valentina Gandin, Liangqi Xie, Lihua Wang, Andrew L. Lemire, Wenhong Li, Hideo Otsuna, Takashi Kawase, Arthur D. Lander, Howard Y. Chang, Zhe J. Liu
The paper investigates how 3D genome organization, specifically through Cohesin, influences gene co-expression in single cells and reveals its role in maintaining long-range chromatin interactions.
Nature Genetics · Jul 24, 2024Peer-reviewedGenomics