Andrew L. Lemire

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

The paper introduces WHOLISTIC, a method to image cellular activity across all organs of a vertebrate, revealing body-wide circuits and responses to stimuli.

Neuronal heterogeneity in the medial septum and diagonal band of Broca: classes and continua

This study uses single-cell RNA sequencing to describe neuronal heterogeneity in the medial septum and diagonal band of Broca, identifying subclusters and explaining conflicting behavioral results.

Spatial organization of the 3D genome encodes gene co-expression programs in single cells

The paper investigates how 3D genome organization, specifically through Cohesin, influences gene co-expression in single cells and reveals its role in maintaining long-range chromatin interactions.

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

Sharp cell-type-identity changes differentiate the retrosplenial cortex from the neocortex

The paper identifies sharp cell-type changes at the granular-dysgranular border in the mouse retrosplenial cortex, showing distinct cell-type compositions compared to the neocortex.

Multimodal mapping of cell types and projections in the central nucleus of the amygdala

This study maps cell types and axon projections in the central nucleus of the amygdala using single-cell RNA-sequencing and spatial techniques, revealing distinct molecular and connectivity patterns.

The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease

Spatially patterned excitatory neuron subtypes and circuits within the claustrum

The paper identifies two excitatory neuron subtypes in the claustrum with distinct molecular and circuit properties, revealing a core-shell spatial arrangement that reconciles conflicting views on its extent.

A novel family of secreted proteins linked to plant gall development

The paper identifies a novel family of secreted proteins, BICYCLE, in aphids that are associated with plant gall development through differential gene expression.

Expansion-Assisted Iterative-FISH defines lateral hypothalamus spatio-molecular organization

The paper introduces EASI-FISH, a method for spatial gene expression profiling in thick brain sections, and applies it to discover novel subregions in the lateral hypothalamus.

Neuron-type specificity of dorsal raphe projections to ventral tegmental area

The paper investigates DR to VTA projections in mice using single-cell RNA sequencing, showing anatomical and functional specificity of serotonergic and glutamatergic neurons.

Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

The paper shows nitric oxide acts as a cotransmitter in dopaminergic neurons to modulate memory dynamics in Drosophila.

A single spectrum of neuronal identities across thalamus

The paper constructs a transcriptomic atlas of the thalamus, revealing a single spectrum of neuronal identities that serve as molecularly-defined filters for cortical modalities.

The Transcriptional Logic of Mammalian Neuronal Diversity

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.

Genetic and transgenic reagents for Drosophila simulans, D.mauritiana, D. yakuba, D. santomea and D. virilis

The paper describes genetic and transgenic reagents for several Drosophila species to facilitate genetic studies.

The genome of the crustacean Parhyale hawaiensis: a model for animal development, regeneration, immunity and lignocellulose digestion

The paper sequences and annotates the genome of Parhyale hawaiensis, identifying key genes for development, immunity, and lignocellulose digestion, providing a resource for comparative studies.