Zhe J. Liu

Plasticity-induced actin polymerization positions endocytic compartments at the bases of stimulated spines

The paper shows that actin polymerization in dendritic shafts positions endocytic compartments at stimulated spine bases, enhancing glutamate receptor turnover and spine enlargement.

Single-particle tracking reveals neuronal activity-dependent shuttling of ARC/ARG3.1 protein between cytoplasmic clusters and the nucleus

This study uses single-particle tracking to show that ARC/ARG3.1 protein shuttles between cytoplasmic clusters and the nucleus in response to synaptic activation.

A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

A series of spontaneously blinking dyes for super-resolution microscopy

This paper introduces a series of spontaneously blinking dyes with adjustable duty cycles for improved single-molecule localization microscopy in cells and dense structures.

Machine learning-guided spatial omics for tissue-scale discovery of cell-type-specific architectures

The paper presents a spatial omics framework combining protein and RNA imaging with machine learning to classify brain cell types and discover structural features at tissue scale.

Deep-tissue spatial omics: imaging whole-embryo transcriptomics and subcellular structures at high spatial resolution

This paper introduces cycleHCR technology for high-resolution spatial transcriptomics and protein imaging in thick tissues, demonstrating its application in mouse embryos and brain slices.

Spatial organization of the 3D genome encodes gene co-expression programs in single cells

The paper investigates how 3D genome organization, specifically through Cohesin, influences gene co-expression in single cells and reveals its role in maintaining long-range chromatin interactions.

Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking

The paper investigates how actin polymerization in dendritic shafts regulates the trafficking of AMPA receptor-containing vesicles during long-term potentiation.

Assessing the impact of Brd2 depletion on chromatin compartmentalization

This study reanalyzes Brd2 depletion effects on chromatin compartments using Micro-C data and cooltools, showing persistent but reduced compartment strength changes.

Nanometer-Scale Imaging of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.

Genome-wide analysis of transcriptional bursting-induced noise in mammalian cells

This study investigates transcriptional bursting kinetics in mESCs using scRNA-seq and identifies regulatory factors and pathways influencing gene expression noise.

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity

The paper shows that astrocytes detoxify fatty acids from hyperactive neurons through mitochondrial oxidation, protecting neurons from toxicity.

MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

This study uses live-cell imaging to show MeCP2 has unique diffusion and chromatin binding kinetics in neurons, distinct from transcription factors and histones.