Lihua Wang

Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

Neuronal heterogeneity in the medial septum and diagonal band of Broca: classes and continua

This study uses single-cell RNA sequencing to describe neuronal heterogeneity in the medial septum and diagonal band of Broca, identifying subclusters and explaining conflicting behavioral results.

Spatial organization of the 3D genome encodes gene co-expression programs in single cells

The paper investigates how 3D genome organization, specifically through Cohesin, influences gene co-expression in single cells and reveals its role in maintaining long-range chromatin interactions.

Sharp cell-type-identity changes differentiate the retrosplenial cortex from the neocortex

The paper identifies sharp cell-type changes at the granular-dysgranular border in the mouse retrosplenial cortex, showing distinct cell-type compositions compared to the neocortex.

Multimodal mapping of cell types and projections in the central nucleus of the amygdala

This study maps cell types and axon projections in the central nucleus of the amygdala using single-cell RNA-sequencing and spatial techniques, revealing distinct molecular and connectivity patterns.

Spatially patterned excitatory neuron subtypes and circuits within the claustrum

The paper identifies two excitatory neuron subtypes in the claustrum with distinct molecular and circuit properties, revealing a core-shell spatial arrangement that reconciles conflicting views on its extent.

Neuron-type specificity of dorsal raphe projections to ventral tegmental area

The paper investigates DR to VTA projections in mice using single-cell RNA sequencing, showing anatomical and functional specificity of serotonergic and glutamatergic neurons.

Distinct descending motor cortex pathways and their roles in movement

The paper identifies two types of motor cortex neurons with distinct roles in movement preparation and execution using single-cell profiling and axonal reconstructions.

A single spectrum of neuronal identities across thalamus

The paper constructs a transcriptomic atlas of the thalamus, revealing a single spectrum of neuronal identities that serve as molecularly-defined filters for cortical modalities.

The Transcriptional Logic of Mammalian Neuronal Diversity

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.