Engineering lung-sensing T cells using synthetic receptors targeting RAGE
Anjali Jacob, Caroline Whitty, Gian Luca Lupica-Tondo, Eshan S Badwal, Xin Ren, Wenli Qiu, Wei Yu, Yurie Tonai, Juan A. Cámara, Milos Simic, Wendell A. Lim, Greg M. Allen, Dean Sheppard
This paper engineers T cells with synthetic receptors that activate only in the lung, demonstrating RAGE as a lung-specific target for targeted therapies.
bioRxiv · Jun 6, 2025 · PreprintSynthetic Biology