Caroline Whitty

Inhibition of integrin αvβ8-mediated TGFβ activation and active-TGFβ blockade promote anti-tumor immunity through distinct biological mechanisms

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

Engineering lung-sensing T cells using synthetic receptors targeting RAGE

This paper engineers T cells with synthetic receptors that activate only in the lung, demonstrating RAGE as a lung-specific target for targeted therapies.